General Information

  • ID:  hor005250
  • Uniprot ID:  C0HJV1
  • Protein name:  Calcitonin-like peptide 2
  • Gene name:  NA
  • Organism:  Odorrana schmackeri (Schmacker's frog) (Rana schmackeri)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Odorrana (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SCNLSTCATHNLVNELNKFDKSKPSSGGVGPESF
  • Length:  34
  • Propeptide:  SCNLSTCATHNLVNELNKFDKSKPSSGGVGPESF
  • Signal peptide:  NA
  • Modification:  T34 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  2-7
  • Structure ID:  AF-C0HJV1-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-C0HJV1-F1.pdbhor005250_AF2.pdbhor005250_ESM.pdb

Physical Information

Mass: 415771 Formula: C151H239N43O53S2
Absent amino acids: IMQRWY Common amino acids: S
pI: 7.25 Basic residues: 4
Polar residues: 17 Hydrophobic residues: 8
Hydrophobicity: -52.35 Boman Index: -5976
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 54.41
Instability Index: 5537.65 Extinction Coefficient cystines: 125
Absorbance 280nm: 3.79

Literature

  • PubMed ID:  NA
  • Title:  De novo sequencing of two novel peptides homologous to calcitonin-like peptides, from skin secretion of the Chinese Frog, Odorrana schmackeri.